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    At-Home Sperm DNA Fragmentation Test | DFI Only

    $299.00

    For men who have already completed a semen analysis and need DNA fragmentation testing only.

    Not a first-line fertility test. If you have not already completed a semen analysis, start with Comprehensive, or choose Advanced, which includes semen analysis, DNA fragmentation, and vitality.

    This test reports the DNA Fragmentation Index (DFI), the percentage of sperm with damaged genetic material. DFI evaluates a dimension of sperm quality that concentration, motility, and morphology do not capture. Each specimen is analyzed in a CLIA-certified, CAP-accredited high-complexity andrology laboratory. Results are available within 24 hours of lab receipt and formatted for physician review.

    Includes:
     ✓ DNA Fragmentation Index (DFI) – SCD/Halo with five halo classifications
     ✓ Sperm microscopy images and videos for physician review
    ✓ Simplified patient report and physician laboratory report
    ✓ CLIA-certified, CAP-accredited lab analysis
    ✓ Validated sample transport
     ✓ MateIQ

    Is this the right test for me?
     This standalone test is intended for men who have already completed a semen analysis, typically with core parameters within reference ranges, but still have a specific reason to evaluate DNA fragmentation. It is also designed for men repeating a previous DFI test.  Four situations fit:

    • Recurrent pregnancy loss. For couples with recurrent pregnancy loss, the AUA/ASRM male infertility guideline recommends evaluating the male partner with sperm DNA fragmentation. ASRM’s 2026 recurrent pregnancy loss guidance adds that DFI testing may be considered in otherwise unexplained recurrent miscarriage or recurrent miscarriage with concomitant infertility.
    • Unexplained infertility after a normal semen analysis. Up to 20% of men with unexplained infertility and normal core semen parameters may have elevated DNA fragmentation (Esteves et al., Andrologia, 2021).
    • Repeat DFI testing. You previously had elevated DFI and want to retest after physician-directed treatment, lifestyle changes, or time. Sperm development takes roughly three months, so physicians often recommend retesting on that timeline.
    • Your physician specifically requested DFI. Your physician, reproductive urologist, or fertility clinic has specifically recommended a sperm DNA fragmentation test.

    Want to understand the science and guidelines? Learn more about sperm DNA fragmentation.

    Who should not start here
    If you have not already completed a semen analysis, this is not the right first test. DNA fragmentation testing does not measure sperm concentration, motility, morphology, or the other core parameters evaluated in a semen analysis, and medical guidelines place semen analysis at the start of the male fertility evaluation.

    CLIA-certified, CAP-accredited

    Analyzed in a high-complexity andrology laboratory

    WHO 6th Edition (2021) methodology

    Most recent WHO semen analysis standard

    Active Cooling transport

    Validated sample transport, preserved until analysis

    Results in 24 hours

    With MateIQ interpretation included

    View Analytical Validation Report Explore the science behind our testing
    How It Works

    Order. Collect. Ship. Understand.

    01

    Order your kit

    Your at-home semen analysis kit ships in discreet packaging, no appointment or clinic visit required.

    02

    Collect from home

    Follow the simple instructions and collect in your own space, on your own schedule.

    03

    Ship your sample

    Drop off your pre-labeled kit at FedEx. Your sample ships Priority Overnight to our CLIA-certified, CAP-accredited lab, while Active Cooling helps maintain it below 15°C for up to 34 hours in transit.

    04

    Results + MateIQ

    Results are delivered in 24 hours through your secure portal, with MateIQ to help explain your report and help you prepare questions for your physician.

    Your Guide to Using Our
    At-Home Fertility Test Kit

    ▶ Watch Instruction Video
    Our Products

    Choose the level of insight you need

    At-Home Comprehensive Semen Analysis
    20 Clinical Parameters

    At-Home Comprehensive Semen Analysis

    The starting point for male fertility evaluation.

    Best for couples beginning the fertility journey, or if your partner has already started testing. More semen parameters than your typical semen analysis.

    • 20 clinical semen parameters
    • FedEx Priority Overnight shipping included
    • Validated specimen transport (Active Cooling)
    • Simplified patient report & physician lab report
    • MateIQ - AI-powered report interpretation
    • Results in 24 hours
    $249.00
    Learn More
    At-Home Advanced Semen Analysis
    DNA + Vitality

    At-Home Advanced Semen Analysis

    For couples who want additional sperm quality testing.

    Best for couples who have been trying without clear answers, are exploring IUI or IVF, or want the most complete semen analysis option.

    • DNA Fragmentation Index – genetic integrity
    • Vitality testing – % of live vs. non-viable sperm
    • Sperm microscopy images for physician review

    Includes everything in Comprehensive: FedEx Priority Overnight shipping, Active Cooling transport, patient and physician reports, MateIQ, and 24-hour results.

    $440.00
    Learn More
    At-Home Post-Vasectomy Analysis
    Post-Vasectomy

    At-Home Post-Vasectomy Analysis

    For confirming whether sperm remains after vasectomy.

    Best if your physician has requested post-vasectomy confirmation testing, without a clinic visit.

    • Residual sperm detection down to 0.01 M/mL
    • Quantitative post-vasectomy semen analysis
    • Reports whether sperm are detected for physician review
    • Aligned with AUA guidance for mail-in specimens
    • Results in 24 hours
    $199.00
    Learn More
    HSA/FSA Eligible

    Frequently Asked Questions

    Find answers to common questions about our products, services, and policies.

    Shipping Information

    Do I need a semen analysis before ordering this test?

    Yes, you should already have completed one. This test reports DNA Fragmentation Index only. It does not measure sperm count, motility, morphology, or other core semen parameters, and medical guidelines place semen analysis at the start of the male fertility evaluation. If you have not had a semen analysis, start with Comprehensive, or choose Advanced, which includes core semen parameters and DFI in one test.

    What is the difference between this test and Advanced Semen Analysis?

    Advanced reports 22 parameters: 20 clinical semen parameters plus DNA Fragmentation Index and vitality. This standalone test reports DFI only. It exists for men who have already completed a semen analysis and now have a specific reason to add DFI. If you need both, Advanced is the more complete and more economical option.

    Can I have elevated DNA fragmentation with a normal semen analysis?

    Yes. A man can have normal sperm concentration, motility, and morphology while still having elevated DNA fragmentation. Research has found elevated sperm DNA fragmentation in up to 20% of men with unexplained infertility despite otherwise normal core semen parameters. Read the research: Esteves et al., Andrologia, 2021.

    What is a normal DFI?

    DFI is reported as the percentage of sperm with fragmented DNA. Mate Health’s laboratory reports DFI against a reference range of below 30%, consistent with commonly cited thresholds for the SCD method. Interpretation thresholds vary across the medical literature, so your result should be considered in the context of your broader fertility evaluation. MateIQ helps explain your specific result and prepare questions to review with your physician.

    Can DNA fragmentation be improved, and when should I retest?

    Some factors associated with elevated sperm DNA fragmentation, including smoking, varicocele, febrile illness, and other sources of oxidative stress, may be modifiable or treatable. Because sperm development occurs over roughly three months, a physician may recommend addressing contributing factors and retesting after about three months. This standalone test is designed for repeat testing. Research is still needed to determine whether interventions that lower sperm DNA fragmentation improve pregnancy outcomes.

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