Skip to main content

    At-Home Advanced Semen Analysis

    $440.00

    A clinical-grade, at-home semen analysis that includes all 20 clinical semen parameters, plus DNA fragmentation index and vitality testing, for a more complete view of male fertility and sperm quality.

    Each sample is analyzed in a CLIA-certified, CAP-accredited high complexity andrology laboratory using WHO 6th Edition methodology. Results are available within 24 hours and formatted for physician review.

    Includes:
    ✓ All 20 clinical semen parameters
    ✓ DNA fragmentation index
    ✓ Vitality testing
    ✓ CLIA-certified, CAP-accredited lab analysis
    ✓ WHO 6th Edition methodology
    ✓ Validated sample transport
    ✓ MateIQ

    Why DNA fragmentation matters
    DNA fragmentation measures damage to the genetic material sperm carry, something count, motility, and morphology cannot reveal on their own. Sperm DNA fragmentation can add information beyond a routine semen analysis and is relevant in unexplained infertility, recurrent pregnancy loss, and assisted reproduction outcomes.
    This is why some men choose Advanced from the start, and others come to it after a normal result that leaves questions unanswered.

    Why vitality matters
    Vitality testing measures the percentage of live sperm in a sample. If motility is low, one key question matters: are the non-moving sperm alive or not? Live but immotile sperm can point toward different causes and different options than non-viable sperm, information that affects how results are interpreted and what next steps may be appropriate. Vitality is reported with microscopy images.

    HSA FSA

    CLIA-certified, CAP-accredited

    Analyzed in a high-complexity andrology laboratory

    WHO 6th Edition (2021) methodology

    Most recent WHO semen analysis standard

    Active Cooling transport

    Validated sample transport, preserved until analysis

    Results in 24 hours

    With MateIQ interpretation included

    How It Works

    Order. Collect. Ship. Understand.

    01

    Order your kit

    Your at-home semen analysis kit ships in discreet packaging, no appointment or clinic visit required.

    02

    Collect from home

    Follow the simple instructions and collect in your own space, on your own schedule.

    03

    Ship your sample

    Drop off your pre-labeled kit at FedEx. Your sample ships Priority Overnight to our CLIA-certified, CAP-accredited lab, while Active Cooling helps maintain it below 15°C for up to 34 hours in transit.

    04

    Results + MateIQ

    Results are delivered in 24 hours through your secure portal, with MateIQ to help explain your report and help you prepare questions for your physician.

    Your Guide to Using Our
    At-Home Fertility Test Kit

    ▶ Watch Instruction Video

    Frequently Asked Questions

    Find answers to common questions about our products, services, and policies.

    Frequently Asked Questions

    What does the Advanced At-Home Semen Analysis include that Comprehensive does not?

    The Advanced At-Home Semen Analysis reports all 20 parameters from the Comprehensive analysis, plus two advanced markers: DNA fragmentation index and vitality testing. It also includes sperm microscopy images for physician review, giving you and your physician a more complete evaluation.

    What is sperm DNA fragmentation, and why does it matter?

    DNA fragmentation measures damage to the genetic material sperm carry, something sperm count, motility, and morphology cannot reveal on their own. It is most often considered in cases of unexplained infertility, recurrent pregnancy loss, or when assisted reproduction is being planned. Up to 20% of men with unexplained infertility and normal routine semen parameters may have elevated DNA fragmentation.

    What does sperm vitality testing add?

    Vitality testing measures the percentage of live sperm in a sample. When motility is low, it helps show whether non-moving sperm are alive or non-viable, useful clinical context that motility alone does not provide. Vitality results are reported with microscopy images for physician review

    Who should consider the Advanced test over Comprehensive?

    Some men choose Advanced from the start for the most complete picture. Others come to it after a normal result that leaves questions unanswered. It is frequently considered in cases of unexplained infertility or recurrent pregnancy loss, situations where DNA fragmentation and vitality can add context. Whether it is right for you is a decision to make with your physician.

    Why does Advanced include sperm images for physician review?

    Microscopy images let a physician see the sample directly rather than relying on numbers alone. For markers like morphology and vitality, visual confirmation adds transparency and supports physician interpretation of your results.

    What type of sperm DNA fragmentation test does Mate Health use?

    Mate Health uses the Sperm Chromatin Dispersion method, also known as the SCD or Halo test, to measure sperm DNA fragmentation and calculate the DNA Fragmentation Index, or DFI. Testing is performed using the FDA-cleared Medical Electronic Systems SQA-Vision platform, with sperm classified according to the five halo categories described in the WHO 6th Edition.

    DNA fragmentation testing is included with Mate Health Advanced Semen Analysis. Patients collect at home, and testing is performed in a CLIA-certified, CAP-accredited high-complexity andrology laboratory.