{"product_id":"dna-fragmentation","title":"At-Home Sperm DNA Fragmentation Test | DFI Only","description":"\u003cp dir=\"ltr\"\u003e\u003cspan\u003eFor men who have already completed a semen analysis and need DNA fragmentation testing only.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eNot a first-line fertility test. If you have not already completed a semen analysis, start with Comprehensive, or choose Advanced, which includes semen analysis, DNA fragmentation, and vitality.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eThis test reports the DNA Fragmentation Index (DFI), the percentage of sperm with damaged genetic material. DFI evaluates a dimension of sperm quality that concentration, motility, and morphology do not capture. Each specimen is analyzed in a CLIA-certified, CAP-accredited high-complexity andrology laboratory. Results are available within 24 hours of lab receipt and formatted for physician review.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp role=\"presentation\" dir=\"ltr\"\u003e\u003cstrong\u003eIncludes:\u003c\/strong\u003e\u003cspan\u003e\u003cbr\u003e\u003c\/span\u003e\u003cspan\u003e ✓ \u003cmeta charset=\"utf-8\"\u003e \u003cmeta charset=\"utf-8\"\u003eDNA Fragmentation Index (DFI) – SCD\/Halo with five halo classifications\u003c\/span\u003e\u003cspan\u003e\u003cbr\u003e\u003c\/span\u003e\u003cspan\u003e ✓ \u003cmeta charset=\"utf-8\"\u003e \u003cmeta charset=\"utf-8\"\u003eSperm microscopy images and videos for physician review\u003c\/span\u003e\u003cbr\u003e✓ \u003cmeta charset=\"utf-8\"\u003e\u003cmeta charset=\"utf-8\"\u003eSimplified patient report and physician laboratory report\u003cbr\u003e✓ \u003cmeta charset=\"utf-8\"\u003e\u003cmeta charset=\"utf-8\"\u003eCLIA-certified, CAP-accredited lab analysis\u003cbr\u003e✓ \u003cmeta charset=\"utf-8\"\u003e\u003cmeta charset=\"utf-8\"\u003eValidated sample transport\u003cspan\u003e\u003cbr\u003e\u003c\/span\u003e\u003cspan\u003e ✓ MateIQ\u003c\/span\u003e\u003cspan\u003e\u003c\/span\u003e\u003cstrong\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\" role=\"presentation\"\u003e\u003cstrong\u003eIs this the right test for me?\u003c\/strong\u003e\u003cspan\u003e\u003cbr\u003e\u003c\/span\u003e\u003cspan\u003e\u003cmeta charset=\"utf-8\"\u003e \u003cmeta charset=\"utf-8\"\u003eThis standalone test is intended for men who have already completed a semen analysis, typically with core parameters within reference ranges, but still have a specific reason to evaluate DNA fragmentation. It is also designed for men repeating a previous DFI test.  Four situations fit:\u003cmeta charset=\"utf-8\"\u003e \u003cmeta charset=\"utf-8\"\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli dir=\"ltr\"\u003e\n\u003cstrong\u003eRecurrent pregnancy loss. \u003c\/strong\u003e\u003cspan\u003eFor couples with recurrent pregnancy loss, the AUA\/ASRM male infertility guideline recommends evaluating the male partner with sperm DNA fragmentation. ASRM’s 2026 recurrent pregnancy loss guidance adds that DFI testing may be considered in otherwise unexplained recurrent miscarriage or recurrent miscarriage with concomitant infertility.\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli dir=\"ltr\"\u003e\n\u003cspan\u003e\u003cstrong\u003eUnexplained infertility after a normal semen analysis.\u003c\/strong\u003e \u003c\/span\u003e\u003cspan\u003eUp to 20% of men with unexplained infertility and normal core semen parameters may have elevated DNA fragmentation (\u003ca href=\"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/and.13874\" target=\"_blank\" rel=\"noopener\"\u003eEsteves et al., Andrologia, 2021\u003c\/a\u003e).\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli dir=\"ltr\"\u003e\n\u003cspan\u003e\u003cstrong\u003eRepeat DFI testing.\u003c\/strong\u003e \u003c\/span\u003e\u003cspan\u003eYou previously had elevated DFI and want to retest after physician-directed treatment, lifestyle changes, or time. Sperm development takes roughly three months, so physicians often recommend retesting on that timeline.\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli dir=\"ltr\"\u003e\n\u003cspan\u003e\u003cstrong\u003eYour physician specifically requested DFI.\u003c\/strong\u003e \u003c\/span\u003e\u003cspan\u003eYour physician, reproductive urologist, or fertility clinic has specifically recommended a sperm DNA fragmentation test.\u003c\/span\u003e\u003cspan\u003e\u003cbr\u003e\u003c\/span\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp dir=\"ltr\" role=\"presentation\"\u003eWant to understand the science and guidelines? \u003ca href=\"mate.health\/pages\/dna-fragmentation\"\u003eLearn more about sperm DNA fragmentation.\u003c\/a\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\" role=\"presentation\"\u003e\u003cstrong\u003eWho should not start here\u003cbr\u003e\u003c\/strong\u003e\u003cmeta charset=\"utf-8\"\u003e\u003cmeta charset=\"utf-8\"\u003eIf you have not already completed a semen analysis, this is not the right first test. DNA fragmentation testing does not measure sperm concentration, motility, morphology, or the other core parameters evaluated in a semen analysis, and medical guidelines place semen analysis at the start of the male fertility evaluation.\u003cbr\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli dir=\"ltr\"\u003e\n\u003cstrong\u003eStarting your fertility evaluation? \u003c\/strong\u003e\u003ca href=\"https:\/\/mate.health\/products\/comprehensive-semen-analysis-test\"\u003eStart with Comprehensive. \u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli dir=\"ltr\"\u003e\n\u003cstrong\u003eWant semen analysis and DFI from the beginning? \u003c\/strong\u003e\u003ca href=\"https:\/\/mate.health\/products\/comprehensive-semen-analysis-test\"\u003eChoose Advanced. \u003c\/a\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Mate Health","offers":[{"title":"Default Title","offer_id":49575355711703,"sku":null,"price":299.0,"currency_code":"USD","in_stock":false}],"url":"https:\/\/mate.health\/products\/dna-fragmentation","provider":"Mate Health","version":"1.0","type":"link"}